Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
4. No talking during the game, wait for half-time or end of the game.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
23% of wealthy Chinese women work in real estate and 18% of them are involved in finance and investment, followed by manufacturing accounting for 14%.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Ranked 10th position, Industrial and Commercial Bank of China is the highest ranking Chinese company on the list.
Trends and targets in antiviral phototherapy
Having earned a living for the last four years while her contemporaries go to school every day, she has been forced to mature quickly.
Financial advisors and asset allocators who had been hoping to see some benefit this year from tactical strategies were also not spared the punishment of a capricious market. Of the top three tactical strategies in the country (Mainstay Marketfield, Good Harbor U.S. Tactical Core, F-Squared Premium AlphaSector Index), two had nearly imploded with double-digit losses while the third found itself under SEC investigation for misleading the public about its historical returns. The other giant tactical manager, Schwab’s $9 billion Windhaven Diversified Growth product, looks to end 2014 with a return close to zero. So much for tactics.
“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Outbound investment for the period totalled $86.3bn, according to the Ministry of Commerce.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Company: The Grommet
ACE2 as a potential therapeutic target for pandemic COVID-19
On this season I have but one thing to say: I love you.值此佳节，我只有一句话要告诉你：我爱你
You're right to be paranoid. The company is always watching you, and there's a record of everything you do: every phone call, every text, every tweet and instant message. At most companies, they save that data forever.
Diagnostic technologies for COVID-19: a review
哈佛大学著名教授格雷厄姆?阿利森(Graham Allison)也警告说，东亚已走向“修昔底德陷阱”(Thucydides’s trap)，他并补充道：“当一个迅速崛起的大国与一个老牌霸权国竞争时，麻烦接踵而来。”2013年初，时任卢森堡首相的让-克洛德?容克(Jean-Claude Juncker)警告称，2013年看起来像1913年一样危险。2013年底，《经济学人》杂志(The Economist)也警告说，“一个世纪已过去，当今世界却与那个导致第一次世界大战爆发的时代有不少相似之处，令人不安。”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
2. Dominos. Brand love: -11% / Rank: 62
Over 11 million new urban jobs, and a registered urban unemployment rate within 4.5 percent.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
节目37 相声《东西南北大拜年》，赵炎 逗笑 逗乐 大新等
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Mr. Murray came to her with a full beard, so she was able to shape it into the thick, bushy mustache pictured here. “Bill has never worn that look before,” Ms. Hannon said, “so it was lovely to get something new.”
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
6. Google Adwords Keyword Planner
Cristiano Ronaldo, the superstar footballer who earned 61 million pound last year, usurped long-term leader Floyd Mayweather Jnr into first place. The retired boxer, who fought just once in the last 12 months, earned pound 30 million.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
美国大学与雇主协会（National Association of Colleges and Employers）进行的一项新研究表明，48%的美国公司计划于2011年招募物流专业研究生。供应链管理人才稀缺的现象，恰恰印证了这一调研结果。
It uses its QQ chat application as a means to drive users to its online games and websites. Analysts say a similar model could work well for WeChat, though they also say that WeChat's Circles function adds a social networking component to the service that could eventually attract advertisers.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
At its own auction the following evening, Sotheby’s achieved a far more respectable total of 22.6 million with fees, although it was just above the low estimate of 21.8 million based on hammer prices. Of the 44 lots offered, 15 did not sell, or 34 percent.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The 8 per cent year-on-year drop in profits last month compares with 4.2 per cent in November and is the biggest since the current data series began in late 2011, figures released on Tuesday showed.
Letizia Battaglia chronicled Palermo’s Mafia wars in the 1970s and ’80s for a local newspaper. Now, her images appear in museums and retrospectives.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
As the stars' private jets swooped in, the internet was going mad for 'the Dad bod'; the slightly flabby male physique was trending and there were plenty of examples on screen. Deborah Cole of AFP noted a “sweating, panting and shirtless” Gerard Depardieu in Valley of Love and a flash of Joaquin Phoenix's “tubby tummy” in Woody Allen's Irrational Man. When Colin Farrell strode the red carpet for the premiere of The Lobster, he looked his usual trim self – but in the film he is distinctly paunchy. To add some girth for the role of a lonely singleton in Yorgos Lanthimos' absurdist black comedy, Farrell went on a massively calorific diet that included drinking melted ice cream, he told the Hollywood Reporter. Eating “two cheeseburgers, fries and Coca-Colas, and two slices of chocolate cake at 10am is not that fun,” he said. “And I love cheese?burgers."
Across all European schools, the average salary of alumni three years after graduation ranges from $143,000 for executive MBA graduates to $54,000 for MiM graduates. MBA graduates earned on average $123,000. Spanish and German MiM graduates enjoyed the highest salary three years after graduation, both $70,000 on average. French MBA graduates and Swiss EMBA graduates top their salary scale, with average salaries of $137,000 and $166,000 respectively.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
'In the meantime, the U.S. continues to grow its own domestic production both in oil and gas. I think, for us, it's less about where the actual price is going--it's more about how much more growth is left in North American oil sands, shale gas, shale oil,' as well as shale exploration elsewhere, he said.
Inhibition of SARS coronavirus helicase by bismuth complexes
A hilarious video showed the swaying crowds singing Can’t Take My Eyes Off You and Hey Baby to the laughing young woman in Bordeaux.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
It was addressed to Clark C Moore, who has since changed his name to Muhammad Siddeeq, making it hard to trace him.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Don't ever tell me that you have to have this job because you're going to lose your house, your kids have nothing to eat, your mother has cancer. Companies aren't a charity.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
1.It wasn’t me! – Because some things just aren’t worth taking credit for。
《一名拍摄黑手党的西西里摄影师和她的“鲜血档案”》(A Sicilian Photographer of the Mafia and Her ‘Archive of Blood’)
He Fan, economist at Caixin, said:“This shows that the macro economy has moved further toward stable growth and the economic structure is improving. Future fiscal and monetary policies must be coordinated and large-scale stimulus should be avoided as much as possible.”
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The residents of the Hankou Binjiang estate had been moved out weeks before.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Yahoo CEO Marissa Mayer
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The Irish. They sing, dance, drink and sing some more. The lads were singing lullabies to a little baby in Bordeaux to try and get it to go to sleep.
One key thing the best bosses seem to have in common is that they are all consummate problem solvers. They can not only spot them, but brainstorm successful and innovative ways to fix them。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
"They are fairies. Can’t they do something else except falling in love?" another Douban user Amy said.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Explaining the choice, the company cited “societal movements toward gender equality and fluidity, the consumer’s increased comfort with using color as a form of expression, a generation that has less concern about being typecast or judged and an open exchange of digital information that has opened our eyes to different approaches to color usage.”
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
About now, new CEO Gorman is probably learning that the meager profits of a retail brokerage can't pay for all those monster Wall Street bonuses. Expect Gorman to decide that Morgan Stanley should be a lot more like trader Goldman Sachs, after all.
In 2016, we've seen a whole lot of new gadgets join the Internet of Things (unfortunately, we've also seen them harnessed by hackers to bring downhuge swaths of the internet). From appliances to clothing, companies really want to sell you the tech that'll make your life "smarter," but sometimes it just makes it slower and dumber. Let's look back on some of the most ridiculous and useless internet-connected gadgets that were produced in the past 12 months.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
More than 110 new and returning series made the shortlist for this roundup before being whittled down to the 20 that appear here. (And that’s without the HBO shows “True Detective,” which is being moved to later in the year, and “Game of Thrones,” “Veep” and “Silicon Valley,” whose April premiere dates haven’t been announced.) From a “Breaking Bad” spinoff, to the return of “Broadchurch,” to the final season of “Justified,” the winter is high season for the serious TV watcher.
7.M·A·S·H Star Never Signed his Contract
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Paul was a pretty undersized guard back in high school, which is probably why he's developed such a "me against the world" mentality. CP3 is one of the grittiest and toughest players in the NBA, and he has to be because he sure isn't one of the biggest.
She suffered anorexia while in an abusive relationship after she arrived in Los Angeles.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Will Smith had a very successful career in the late 80s and early 90s as the second half of rap duo DJ Jazzy Jeff and the Fresh Prince. But in spite of his financial success, Smith did not manage his money well. It's a pretty classic tale, really. New fame, lots of money, no future plans, and lots of fancy toys added up to a lot of overspending. This lack of oversight and fiscal irresponsibility landed him on the brink of bankruptcy. He owed the government back taxes that he had not paid.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Meanwhile, exports are expected to continue falling due to the combination of weak global demand and higher prices, as well as China’s decision to effectively re-peg the renminbi to the strengthening dollar.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Joss Whedon came up with the idea of Firefly while he was on a non-working vacation. He was reading a book called The Killer Angels which told the story of soldiers in the Battle of Gettysburg. Whedon was attracted to the idea of the difficulty of the soldiers' everyday lives. He liked that the author focused on the mundane details of how people survived when they didn't have all of their needs conveniently met by modern technology and commercialism.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
上述消息源还称，苹果将在明年10月发布一款12.9英寸的平板电脑，“目标消费群是北美的教育市场（和）……生产商是广达电脑（Quanta Computer）”。有报道称，三星也在研发尺寸在12至13英寸之间的平板电脑，而现在看来，“这些大尺寸平板电脑将极大地影响超极本需求”几乎是板上钉钉的事了。新款“iPad Max”，搭载整合了键盘和电池的新款外壳之后，实际上就是一台笔记本电脑，很有可能在高中生和大学生之中成为主流产品——这一人群需要比现有iPad和iPad Mini产品更好的内容创造工具。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
At the same time, she said, other countries have seen their tourist numbers spike as the currencies weaken.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
3. Feng Shui
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Forex reserves fell $87bn in November, near the record $94bn decline suffered in August — the same month that the central bank surprised global markets by allowing the renminbi to depreciate by 3 per cent in three days.
US News also offers subject-focused rankings, which include popular fields such as computer science, economics and business and engineering.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Well, that’s it, kids: we’re heading home. Chinese shares are down 7 per cent, and thanks to the newly-instituted market circuit breakers, that means the market shuts.
Microscopic as the subjects are, the benefits of the scientists’ research are set to be huge.
Intel welcomes its new employees to the company by rolling out the red carpet -- literally -- once a quarter. During the first day of orientation, hires walk along a pathway lined with Intel Studios' photographers and videographers before introducing themselves onstage and receiving their welcome packages (and a round of applause from an audience of new colleagues).
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Inarritu said: "I forgot to thank all the native Americans who made this film possible. I cannot say how surprised I am and how proud I am to have survived this film with all these fellows."
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
8. Taxi driver
The U.S. $10 bill will feature the portrait of a notable U.S. woman by 2020.
Analysts believe the launch will help Apple to overcome its growth problem of the last two years. In markets such as America and Europe, where smartphone ownership is close to saturation and many customers are holding on to their existing handsets for longer, the best way to drive faster revenue growth is by charging more for each device, rather than simply relying on unit growth.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
“If we can identify someone who buys in both places, there is huge value there. You know who they are, what they bought, what they spent,” Harper added. “You can give them a more personalized experience.”
The joint programme delivered by Tsinghua and Insead University (Tiemba) moved up two places to lead the 2015 global executive MBA ranking, dethroning Trium, which drops back to third place after only one year at the top.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
A combination of tax increases and spending cuts in 2013 shaved about 1.5 percentage points off annual economic growth, according to the Congressional Budget Office. Many forecasters expect the fiscal drag in 2014 to be one-third that amount, or less. 'You'll have more political certainty this year,' said Gregory Daco, a U.S. economist at Oxford Economics.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.
STEP 3: PRACTICE CREEPY LOOKS
Length-scale dependence of protein hydration-shell density
Judge Business School at the University of Cambridge jumps five places to fifth. Not only is it the first time it has broken into the top five, but it is also the first occasion that LBS is not the top-placed UK school in the MBA ranking.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
It is based on a survey of business schools and another of their alumni who graduated in 2013.
McCarthy took home $33 million in earnings, up $10 million from 2015.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Countrywide, month-on-month prices rose in 59 out of 70 cities last month – down from 62 – were unchanged in four and fell in eleven. Cities where prices fell from the previous month included Shenzhen (down 0.3 per cent), Hangzhou (down 0.4 per cent) and Xiamen (down 0.2 per cent).
根据租金指导委员会(Rent Guidelines Board)的数据，在过去20年里，纽约市至少有13.3万个单元因这项规定而变成市价房。政策的支持者表示，如果这一趋势持续下去，租金管制政策会被进一步削弱，从而对市长保留保障房的努力构成阻碍。
位于加州的斯坦福大学商学院(Stanford Graduate School of Business)排名第二，2016年排在第五位，该学院曾在2014年获得亚军。宾夕法尼亚大学沃顿商学院(Wharton School of the University of Pennsylvania)排名第三。
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Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.