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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

我们的前路应有尽有,我们的前路一无所有……
“If lenders are too optimistic during market booms and too pessimistic in downturns, that could be a good reason for authorities to set conservative capital requirements,” he suggests. “Higher haircuts might dampen the initial run-ups, but they could also dampen the subsequent fallouts when tides turn.”

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

China (mainland and Hong Kong) adds 25 to the list this year, more than any other country, for a total of 207. Three countries debut on the list this year: Mauritius, Slovakia, and Togo.
这些包括纳米汽车在内的轻巧设计小得甚至连肉眼都不可见。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

尽管中国国内经济放缓,中国对欧洲和美国的投资却达到创纪录高位。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The fundamentals of the Chinese economy remain sound, the capital adequacy ratio and provision coverage of commercial bans remain high, and we have many financial tools and instruments that can be used. We have the confidence, the ability, and the means to forestall systemic risks.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Andrew Bargery, campus and schools engagement leader at PwC, says Teach First graduates stand out: “They have already worked in a professional envir-onment and have professional maturity and are good at building relationships.”
"This film was about survival, adaptation and the triumph of the human spirit and more importantly it was about trust.”
《火线警探》,FX,1月20日。副警长瑞兰·吉文斯(Raylan Givens,蒂莫西·奥利芬特[Timothy Olyphant]饰)与他的朋友兼天敌博伊德·克劳达(Boyd Crowder,沃尔顿·戈金斯[Walton Goggins]饰)之间爱恨交织的关系贯穿了整部剧,不管怎样,这个问题将在第六季,也就是最终季中得到最终解决。
与此同时,还有其他因素在掣肘亚洲ETF市场,一些怀疑者担心,这些因素将阻碍散户市场的发展。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

“这是我们租户运动生死攸关的时刻,”大都会住宅委员会(Metropolitan Council on Housing)的项目总监伊拉娜·迈尔(Ilana Maier)说,“如果我们现在不能大举强化规定,那么这些政策在十年内都发挥不了作用。”
美国
While 221 people fell off the billionaires list this year, 198 people joined the ranks. Twenty-nine from the 2015 list died, while another 29 rejoined the list after having fallen off.
intentionally

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

在佛罗里达州博卡拉顿林恩大学的辩论,在外交政策和安全上奥巴马有一个固有的优势。作为总统,能接触到情报分析员、外交官和将军的每日简报,他能更好的概括,好像在上半场的辩论中他支配着罗姆尼。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

数据还显示,网红的分布和经济发展水平也有密切关系,北京、上海、广东、江苏和浙江等较发达地区是网红分布最多的五个地区。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

联合国世界知识产权组织(WIPO)、英士国际商学院和美国康奈尔大学联合发布的年度报告显示,全球第二大经济体正在赶追创新领域那些传统的领先者。目前,第一集团主要是由瑞士、瑞典、英国和美国引领。
The school ranks first for alumni satisfaction.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 房租异常上涨意味着房价拐点临近
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.
在春运期间,国内的交通运输将面临极大的挑战,车票供小于求。铁路局会采取多种措施来应对春运压力,比如开设临客(L字头的列车)、延长售票时间以及开设更多的售票点。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

6. How to play guitar
中国为包括棉花、糖和玉米在内的大宗商品设置的最低价格过高,当这些价格偏离市场价格时,政府鼓励了过度生产以及强劲的进口。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Annual prices had been rising as much as 9.6 per cent at the start of this year but they've cooled since then as the economy slows and many mid-sized Chinese cities suffer from a glut of apartments.
Julian Evans-Pritchard, China economist at Capital Economics, commented:
格里芬高中时代的样子与现今相差无几,原因是他离开高中才四年。我们能想象得出,暴力美学的格里芬在NBA里再锻炼上一两年年,他会变得更“怪兽”。
China’s foreign exchange reserves posted their third-largest monthly decline on record last month, central bank data showed yesterday, renewing worries about capital outflows after reserves had appeared to stabilise.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

年龄:46岁

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

发行于2013年的《炫富帮》是一部语带讽刺的犯罪剧情片,记录了一帮好莱坞山高中生的冒险,他们偷到了当地名人的家里。少年们进入梅根·福克斯和帕丽斯·希尔顿这样的偶像家,偷走现金、衣服、手袋和珠宝,用来模仿杂志上让他们羡慕的奢华生活。在朋友圈炫耀战利品的照片后,他们终于被抓进了监狱。
据预测,在大宗商品价格上涨和需求温和上升的推动下,2017年以美元计的新兴市场国家出口额将出现自2014年以来的首次增长。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

[.?pti'mistik]

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

In addition, the last quarter of 2016 marked the first time that Huawei achieved a double-digit global market share.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

我们只把精力在应该关注的地方
节目1 开场曲《欢歌贺新春》,中央电视台48位主持人
10月份,中国社会消费品零售总额增长放缓。另一方面,尽管上月出口走弱,中国规模以上工业增加值和全国固定资产投资增长仍大致保持平稳。
我喜欢这个列表(很棒的观点),但是我觉得我要更详细的完善一下怎样成为一个高效老板或者经理。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 9月 “金九银十”恢复平静
Review Article

Influenza neuraminidase: A druggable target for natural products

557,000 people were murdered across the world in 2001 alone. That number significantly dropped by 289,000 by 2008. The homocide rate is now in decline in 75% of nations.
教育部表示:“那些严重破坏考试秩序,损害教育公平公正的人将得到他们应得的惩罚。”
10月份的PPI环比上涨了0.7%,高于9月份0.5%的环比涨幅。
embrace
“听起来,哈佛对学生的私生活管得太宽了”,曾为OJ?辛普森等多位名人做过代理律师的德肖维茨说。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

维多利亚的秘密内衣秀刚刚拉开华丽巨幕,今年的秀也是有史以来最奢华复杂的一次。
They have no reason to tank thanks to the pick swap with the Celtics, but they might be able to pick up some nice consolation draft prizes from contenders looking to make a move.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

现在,她主要在模特行业发展,但是她也很希望跻身演绎圈。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

12岁的年纪,大多数的小女孩都还在向父母争取打耳洞的机会,努力适应高中生活,从青少年时代开始为将来做准备。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

(Actually, JetBlue wasn’t the absolute worst airline for departure delays the last three holiday seasons. That crown went to Comair, a regional carrier for Delta Air Lines
一些深受喜爱的电视剧角色就像老朋友一样存在于我们的生活中,并对我们产生翻天覆地的影响。我们为之捧腹大笑,也为之潸然泪下,甚至不惜撒谎请假,只为能够端坐在电视机前得知他们的最新进展。自始至终,我们对他们如痴如醉。但是还有很多东西是观众无法从银幕上得知的,比如隐藏在这些电视剧中的小秘密。下面就是一些受人追捧的电视剧的幕后故事。
Not only does its small cohort of about 50 allow the school to select highly experienced participants, it also creates a strong bond between them.
社交网络平台,包括微博和手机应用微信,被证明是网红扩大交流的最好工具,使其可以创造出一种囊括广告、电子商务和粉丝的行业。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

We will boost the development of modern agriculture.
ad+(mini小+ster→小人→古代大臣称自己是“小人”→部长,大臣)→做部长→管理,治理+ation→行政,管理
自从18个月前在亚洲设立业务以来,克拉布一直没有涉足香港房地产市场,因为他表示,价格太高了,可担负性太差。
n. 争斗,战斗

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

While British schools moved up two places on average, French schools, the largest group from any one country, fell one place on average. EMLyon Business School dropped outside the MBA ranking and lost 15 places overall, while Edhec Business School failed to make it into the Executive MBA ranking and lost eight places overall as a result.
对于像费城、凤凰城和布鲁克林这样的烂队而言,另一个问题在于他们很难笼络到好的球队拼图。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

France’s HEC Paris and Essec Business School remained second and third, respectively, for the third year running.
伦敦商学院(LBS)连续三年蝉联欧洲商学院排行榜桂冠,但其在欧洲大陆的竞争对手在用于编制榜单的单项排名中领先。
Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.
74个重点城市细颗粒物(PM2.5)年均浓度下降9.1%;
《静待黎明》

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

第一架无线电操纵的无人驾驶飞机可追溯到1916年。英国发明家阿奇博尔德·洛设计并试飞了第一架无人遥控飞机。它是为了反攻德国齐柏林飞艇而制作的,在第一次世界大战中参与了对地面攻击的战斗。无人机由木和锡制成,它的机翼用的是其他双翼飞机的较低机翼。总的来说,无人机是有些失败的,因为它的引擎噪音干扰了无线操作。1916年,索普威斯飞松公司也尝试制作无人机,他们将无线电设备放置在无人机的尾部,这样引擎就不会干扰到它的信号。但因一次地面上的意外事故,他们的无人机再未起飞:当洛操作无人机飞到高级军官面前时,他原本计划会在1917年再次试飞无人机。但无人机从卡车的后面发射后,飞了一段时间便因引擎故障而坠毁,差点要了在场的军官的命。
IE商学院校友在毕业后的薪资平均涨幅方面排在第二位,为39%。在实现目标以及国际流动性方面,该学院排名居首。在职业发展方面,排名第三。“在职业发展方面,攻读在线课程‘前后’确实是有差别的,”该学院的一名校友表示,“读完MBA后,我心中更有方向感了,不仅明白了自己想要达到什么目标,还有为何这么做以及如何达到目标。”
这一发现引起了历史学家的极大关注,因为这为了解理查三世提供了更加确凿的证据。理查三世于1485年死于博斯沃思战役,之后有关他的一生一直充满争议。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

World's Most International Universities Ranking 2016 by The Times Higher Education included 200 universities from 28 countries. It employed indicators such as the proportion of international staff, the number of international students and research papers published with at least one co-author from another country of each institution.
今年银幕上的发型和化妆各式各样,大胆新颖,从《魔法黑森林》(Into the Woods)中女巫卷曲、蓬乱的蓝色调鬃毛,到《激乐人心》(Get On Up)中詹姆斯·布朗(James Brown)微微发亮、精心塑造的大背头。有时,秃头也能发挥作用,比如《法老与众神》(Exodus: Gods and Kings)中拉美西斯的秃头、重眼影造型。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

AMC频道的《广告狂人》(Mad Men)也是如此。该剧演到了第七季,剧中人物和20世纪60年代的背景似乎已被挖掘干净,不过它仍在让观众猜测结局,结局要到明年才播出。《黑道家族》(The Sopranos)结局模糊。《绝命毒师》(Breaking Bad)以沃尔特·怀特(Walter White)死去告终。现在,隐约显现的下一个电视谜题是唐·德雷珀(Don Draper)的最后时刻——究竟是死去还是活着。
vt. 记载,(用文件
数月前,18岁的安娜·费斯·卡尔森在一张艾丽莎的宣传立板边照了张相,发布到了网上,她立刻变成了网络红人。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Chen Lihua, 75, founder of Fu Wah International Group, a company engaged in real estate development, has become China's richest woman with a net worth totaling 50.5 billion yuan, according to the report Richest Women in China 2016 released by Hurun Research Institution.
trans转移+port拿,运→移动着拿→运输
对中国来讲,不发展是最大的风险。我们保持中高速的稳定增长,本身就是在为世界稳定做贡献。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 家装选材 低劣辅材危害猛于虎
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 中小涂料企业有多苦 你知道吗
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

源于:sloth(n (对工作)懒惰)slou=slow,ch吃:吃得慢-无精打采的样子

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

DeMarcus Cousins, Serge Ibaka and Lou Williams were all dealt in advance of Thursday's 3 p.m. ET deadline, leaving role players like Taj Gibson and P.J. Tucker as the biggest names to move right before the buzzer.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

根据这份由互联网薪酬调查及报告提供商中国薪酬网发布的调查显示,清华大学2017届毕业生平均月薪达9065元。
However, others argued that doctors' hands may be forced by an unfair system. "As a patient, I'm more concerned about whether they can cure my illness rather than how many papers they've published," another netizen said.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 酒店业如何搭上“租购并举”东风
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
Bryant is the first player this season with four or fewer points on 14 or more field goal attempts.
n. 路费,食物
丝绸之路上的城市

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Mr Lam predicts that any recovery in the market will rely on appetite from cash-rich companies from mainland China, with foreign investors restricting their investments to real estate investment trusts or stocks exposed to developers, rather than actual property.
与此同时,中国首富王健林等人士对中国国有企业在欧洲投资的事情表示担忧,声称它们缺乏国际管理标准。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
今年2月的时候,在格莱美颁奖典礼上,克里斯汀?韦格和玛蒂?齐格勒为希雅的歌曲《Chandelier》伴舞,希雅背对着观众(图)

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

请做好准备随时当他的救世主。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Mr Cook has added three women to what was previously a white-male-dominated executive team and changed Apple’s board charter to commit to seeking out candidates from minorities when appointing directors.
'I also gave him a very outspoken gay friend, who chides him and says "come on Bond, you're living in the 20th century now not the Middle Ages".
美国的排放量在经过了最近几年的持续下降后,提高了2.9%。
The top 10 Weibo celebrities now have a combined 40 million followers. One of the most famous online figures, Papi Jiang, already signed a contract for video ads worth a staggering 22 million.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

在过去的二十年里,几起校园中毒事件引发了群众对学生心理发展及帮助的争论和关注。
For the government, the job is to create a good environment and the necessary conditions for our people to use their own wisdom and hard work to generate golden opportunities for themselves, rather than just relying on the government to hand them a job.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

201512/415505.shtmlBritish business schools shine in the 2015 Financial Times ranking of European institutions. Not only has London Business School (LBS) kept its crown as the best business school in Europe but three other schools in Britain have achieved the biggest rises since last year.
The 24K pizza is available at Industry Kitchen, an eatery in New York City's South Street Seaport, for a whopping $2,000 and, as the name would suggest, is noted for being covered in flakes of 24-karat gold.
在2009年美国经济开始复苏时,全球其他地区开始陷入各自的困境。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

这样的要求不可谓不苛刻。现在,有上千个供应链岗位正虚位以待。如果你希望谋求此类职位,可行之策是先接受物流培训。目前有许多学院和大学都提供此类培训,其中有些是在线课程,如美国宾州州立大学(Penn State)就提供在线供应链管理研究生培训,并颁发证书。
立场:为禁止员工在家上班进行辩解
中国手机制造巨头华为发布了业务预期,在2016年,其智能手机发货量达到了1.39亿台,同比增长29%,而全球手机出货量的同比增长仅为0.6%。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: “冰丝带”上午全部“跃出”地面
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

野村证券驻首尔策略师Michael Na表示:“这可能只是个开始。要惩罚韩国企业,他们有如此多的选项。”
The military parade in Beijing on Sept. 3 that commemorated the 70th anniversary of the end of World War II was the news event that users looked up the most on Baidu's search platform. The celebration featured thousands of troops marching past President Xi Jinping and his predecessors, Hu Jintao and Jiang Zemin, as well as foreign leaders, including President Vladimir V. Putin of Russia.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

This is not to take anything away from Tesla, which has demonstrated that it can create and manufacture a complex and sophisticated product with demonstrated customer appeal. But its own internal forecasts, as well as the swelling of its share price, are based on the expectation that the future will unspool in an orderly fashion identical to the recent past. That’s a dangerous assumption to make – for several reasons:
Gymnastics;Trampoline;Artistic gymnastics;Rhythmic gymnastics
天生脑瘫的余秀华原本过着平静的乡村生活。现在,她在文坛引起了轰动,她描写情欲的生动诗歌“有明显的血污”。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

7.Manage up, down, and sideways
But John Davies, head of institutional investment in the Hong Kong team at CBRE, the property services business, says that lower prices should make the market more reliable. “The market is showing characteristics of a mature market, which institutional investors understand better,” he says.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Such borrowing is predicated in part on the assumption that by decontextualizing a style you also strip it of any possible negative implications: military, dynastic, what have you. It becomes an aesthetic form that exists on its own terms, as opposed to one that symbolizes all sorts of complicated societal or political convulsions.
但有些人可能就记住了胡子。
挪威诺贝尔和平奖委员会主席亚格兰赞扬这三位女士的成就,还说,除非女性享有和男性一样的机会,否则我们不能实现持久的和平。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 成交下滑 三成中介转行
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Beck “Say Goodbye” (Capitol)

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 特色小镇的核心是大写“特”字
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

普华永道的校园和学校雇佣主管安德鲁?巴杰里(Andrew Bargery)表示,Teach First的毕业生出类拔萃:“他们已经在专业环境下工作过,拥有专业成熟度,并擅长交际。”
11月24日至25日,苏富比举办慕尼黑第四代交易商康拉德·伯恩海默(Konrad Bernheimer)的藏品拍卖会,他拥有历史悠久的伦敦科尔纳吉画廊(Colnaghi)。65岁的伯恩海默决定缩小自己的业务,关闭慕尼黑的画廊,卖掉巴伐利亚的豪华宅邸马尔库斯泰恩城堡(Marquartstein Castle),将科尔纳吉画廊与伦敦的Coll & Cortes画廊合并。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

[str?uk]
优秀的老板们懂得授权的艺术。我的一位评论家说要沿着线走“他们已经从目前的工作里面抽身”,意味着他们不干涉每一天和每一分的工作流程和程序。本质上,学着去授权给员工去代替微化管理是对员工的一种信任。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 北京年底前建千个社区服务用房
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

13. iPhone 提醒
triangle

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

In the ranking of finance programmes for students already working in the industry, London Business School regains the top place it occupied between 2011 and 2015, while Judge Business School at Cambridge university drops back into second place.
6.《我爱你,菲利普·莫里斯》

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Susan Chan, head of iShares Asia-Pacific at BlackRock, says ETFs are more popular among institutional investors in the region.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 52个北京项目落地廊坊北三县
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

布莱恩·肯德罗拉是纽约Stack's Bowers Galleries 拍卖行的行长,他透露这次拍卖吸引了来自6个国家的6名竞拍者。在星期四举行的拍卖会上,中标者是一名匿名的亚洲收藏家。
指数:100.0
仿佛是2016年对中国员工还不够艰难,一项年度调查披露,中国逾半数白领雇员在即将到来的(开销巨大的)农历春节假期来临前没有领到年终奖。
It is believed that the rise of South Korea's pop music industry is behind the boom, and many patients visit clinics with photos of celebrities, asking surgeons to emulate nose angle or eyes.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

在原油市场连续数年获得新兴市场需求的支撑之后,快速增加的原油供应很可能会在2014年拉低油价,油市形势将继续随着这种供需动态变化而发生改变。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

在过去三年失业率已从8.6%降至5.8%,但是包括美联储,几乎没有人认为劳动力市场现在是真的健康。
The central bank last year spent more than six months signaling its intent to wean the economy off a third round of bond-buying, and the prospect upset markets at just about every turn. Now it's only in the first stage of that process.
And the best gig for 2015? That would be an actuary, the people who specialize in financial risk.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 六大基建新任务利好建材业
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

2010年的头号热门搜索问题是“如何打领带”,其次是“如何减肥”、“如何接吻”以及“如何写简历”。
[dr?ft]

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 家居卖场:“过剩”不能一概而论
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

The paperpot transplanter allows a single person to transplant 264 plants covering over 85ft in just minutes. What used to take hours, now takes minutes. Allowing you to spend less time transplanting crops, and more time doing other things like farm improvements, marketing, sales, or just taking some time off.
Since you will be spending so much time in your office space, you should be comfortable enough to enjoy what you do. A comfy chair will keep you pleased throughout the day. We recommend the Allak Swivel Chair, $59.99, at Ikea.com. If you need music to keep your mind stirring, we recommend the Sound System iPod Speaker, $220, at UrbanOutfiters.com.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

这两部极具娱乐性,追求整体效果,建立在事实基础上的程序剧(procedural)都是关于惊人的犯罪与腐败滋生的大型机构的故事——一个是关于罗马天主教会,一个是关于华尔街银行。除了激发起正直的愤怒,麦卡锡与麦凯以不同的方式,把悬疑、情感和道德的分量融入到接电话、敲键盘、读报表等现代日常工作中去。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Fewer women than men have worked abroad for at least six months (42 per cent and 52 per cent respectively) but they share exactly the same motivations — to develop management skills, build their network and increase their earnings.
The high school version of Howard isn't nearly as intimidating as the new one. Just goes to show how much ridiculous hard work goes into becoming an NBA All-Star.
《Trigger Mortis》于9月8日发行,先于10月26日上映的007新电影《(幽灵党(暂译)》(Spectre)。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Alumni from Edhec have the 11th highest average salary, at $105,000, behind the alumni from Sloan at $143,600. They also enjoyed theseventh-highest salary increase, at 79 per cent.
5.布莱恩·克兰斯顿曾是杀人嫌疑犯
Take the intriguing reintroduction of “unfeigned regards” — last big in the 18th century and now found on emails from Indian help centres. But the winning sign-off, at the bottom of a message sent one Friday, was: “weekend well”. I nearly awarded it second prize for the best noun pretending to be a verb, though at the last minute this award was snatched by a consultant overheard saying: “Can we cold towel that?”
荷兰合作银行是面向全球农户和农业企业的领先融资机构。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Two of Summly’s employees will move to Yahoo’s California headquarters, but – for now – Mr D’Aloisio is resisting the lure of Silicon Valley.
Build the armed forces through political work and reform, and run them by law

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The life expectancy of the average human has increased more in the past 50 years than it did in the 200,000 years of human existence. Life expectancy is now 70 years old – which is a big difference from 47 years old in 1950!
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA,简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜,也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
Stand: Facebook CEO Mark Zuckerberg took a stand for immigration reform

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

Folk Song “Jasmine” (Song Zuying and Celine Dion, Canada)
Emma Thompson, a two-time winner for Howards End and Sense and Sensibility, famously keeps hers in the loo: “They look far too outré anywhere else. They’re great big, gold, shiny things.” She’s not alone – Susan Sarandon, Lionel Richie and Sean Connery all claim to keep their golden fellas alongside their bidets and baths.

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