Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
“If lenders are too optimistic during market booms and too pessimistic in downturns, that could be a good reason for authorities to set conservative capital requirements,” he suggests. “Higher haircuts might dampen the initial run-ups, but they could also dampen the subsequent fallouts when tides turn.”
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
China (mainland and Hong Kong) adds 25 to the list this year, more than any other country, for a total of 207. Three countries debut on the list this year: Mauritius, Slovakia, and Togo.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
The fundamentals of the Chinese economy remain sound, the capital adequacy ratio and provision coverage of commercial bans remain high, and we have many financial tools and instruments that can be used. We have the confidence, the ability, and the means to forestall systemic risks.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Andrew Bargery, campus and schools engagement leader at PwC, says Teach First graduates stand out: “They have already worked in a professional envir-onment and have professional maturity and are good at building relationships.”
"This film was about survival, adaptation and the triumph of the human spirit and more importantly it was about trust.”
《火线警探》，FX，1月20日。副警长瑞兰·吉文斯（Raylan Givens，蒂莫西·奥利芬特[Timothy Olyphant]饰）与他的朋友兼天敌博伊德·克劳达（Boyd Crowder，沃尔顿·戈金斯[Walton Goggins]饰）之间爱恨交织的关系贯穿了整部剧，不管怎样，这个问题将在第六季，也就是最终季中得到最终解决。
Trends and targets in antiviral phototherapy
“这是我们租户运动生死攸关的时刻，”大都会住宅委员会(Metropolitan Council on Housing)的项目总监伊拉娜·迈尔(Ilana Maier)说，“如果我们现在不能大举强化规定，那么这些政策在十年内都发挥不了作用。”
While 221 people fell off the billionaires list this year, 198 people joined the ranks. Twenty-nine from the 2015 list died, while another 29 rejoined the list after having fallen off.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The school ranks first for alumni satisfaction.
ACE2 as a potential therapeutic target for pandemic COVID-19
Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.
Diagnostic technologies for COVID-19: a review
6. How to play guitar
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Annual prices had been rising as much as 9.6 per cent at the start of this year but they've cooled since then as the economy slows and many mid-sized Chinese cities suffer from a glut of apartments.
Julian Evans-Pritchard, China economist at Capital Economics, commented:
China’s foreign exchange reserves posted their third-largest monthly decline on record last month, central bank data showed yesterday, renewing worries about capital outflows after reserves had appeared to stabilise.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
In addition, the last quarter of 2016 marked the first time that Huawei achieved a double-digit global market share.
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
557,000 people were murdered across the world in 2001 alone. That number significantly dropped by 289,000 by 2008. The homocide rate is now in decline in 75% of nations.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
They have no reason to tank thanks to the pick swap with the Celtics, but they might be able to pick up some nice consolation draft prizes from contenders looking to make a move.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
(Actually, JetBlue wasn’t the absolute worst airline for departure delays the last three holiday seasons. That crown went to Comair, a regional carrier for Delta Air Lines
Not only does its small cohort of about 50 allow the school to select highly experienced participants, it also creates a strong bond between them.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
We will boost the development of modern agriculture.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
While British schools moved up two places on average, French schools, the largest group from any one country, fell one place on average. EMLyon Business School dropped outside the MBA ranking and lost 15 places overall, while Edhec Business School failed to make it into the Executive MBA ranking and lost eight places overall as a result.
Inhibition of SARS coronavirus helicase by bismuth complexes
France’s HEC Paris and Essec Business School remained second and third, respectively, for the third year running.
Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
World's Most International Universities Ranking 2016 by The Times Higher Education included 200 universities from 28 countries. It employed indicators such as the proportion of international staff, the number of international students and research papers published with at least one co-author from another country of each institution.
今年银幕上的发型和化妆各式各样，大胆新颖，从《魔法黑森林》(Into the Woods)中女巫卷曲、蓬乱的蓝色调鬃毛，到《激乐人心》(Get On Up)中詹姆斯·布朗(James Brown)微微发亮、精心塑造的大背头。有时，秃头也能发挥作用，比如《法老与众神》(Exodus: Gods and Kings)中拉美西斯的秃头、重眼影造型。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
AMC频道的《广告狂人》(Mad Men)也是如此。该剧演到了第七季，剧中人物和20世纪60年代的背景似乎已被挖掘干净，不过它仍在让观众猜测结局，结局要到明年才播出。《黑道家族》(The Sopranos)结局模糊。《绝命毒师》(Breaking Bad)以沃尔特·怀特(Walter White)死去告终。现在，隐约显现的下一个电视谜题是唐·德雷珀(Don Draper)的最后时刻——究竟是死去还是活着。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Chen Lihua, 75, founder of Fu Wah International Group, a company engaged in real estate development, has become China's richest woman with a net worth totaling 50.5 billion yuan, according to the report Richest Women in China 2016 released by Hurun Research Institution.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
DeMarcus Cousins, Serge Ibaka and Lou Williams were all dealt in advance of Thursday's 3 p.m. ET deadline, leaving role players like Taj Gibson and P.J. Tucker as the biggest names to move right before the buzzer.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
However, others argued that doctors' hands may be forced by an unfair system. "As a patient, I'm more concerned about whether they can cure my illness rather than how many papers they've published," another netizen said.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
Bryant is the first player this season with four or fewer points on 14 or more field goal attempts.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Mr Lam predicts that any recovery in the market will rely on appetite from cash-rich companies from mainland China, with foreign investors restricting their investments to real estate investment trusts or stocks exposed to developers, rather than actual property.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Mr Cook has added three women to what was previously a white-male-dominated executive team and changed Apple’s board charter to commit to seeking out candidates from minorities when appointing directors.
'I also gave him a very outspoken gay friend, who chides him and says "come on Bond, you're living in the 20th century now not the Middle Ages".
The top 10 Weibo celebrities now have a combined 40 million followers. One of the most famous online figures, Papi Jiang, already signed a contract for video ads worth a staggering 22 million.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
For the government, the job is to create a good environment and the necessary conditions for our people to use their own wisdom and hard work to generate golden opportunities for themselves, rather than just relying on the government to hand them a job.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
201512/415505.shtmlBritish business schools shine in the 2015 Financial Times ranking of European institutions. Not only has London Business School (LBS) kept its crown as the best business school in Europe but three other schools in Britain have achieved the biggest rises since last year.
The 24K pizza is available at Industry Kitchen, an eatery in New York City's South Street Seaport, for a whopping $2,000 and, as the name would suggest, is noted for being covered in flakes of 24-karat gold.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The military parade in Beijing on Sept. 3 that commemorated the 70th anniversary of the end of World War II was the news event that users looked up the most on Baidu's search platform. The celebration featured thousands of troops marching past President Xi Jinping and his predecessors, Hu Jintao and Jiang Zemin, as well as foreign leaders, including President Vladimir V. Putin of Russia.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
This is not to take anything away from Tesla, which has demonstrated that it can create and manufacture a complex and sophisticated product with demonstrated customer appeal. But its own internal forecasts, as well as the swelling of its share price, are based on the expectation that the future will unspool in an orderly fashion identical to the recent past. That’s a dangerous assumption to make – for several reasons:
Gymnastics；Trampoline；Artistic gymnastics；Rhythmic gymnastics
A modular microarray imaging system for highly specific COVID-19 antibody testing
7.Manage up, down, and sideways
But John Davies, head of institutional investment in the Hong Kong team at CBRE, the property services business, says that lower prices should make the market more reliable. “The market is showing characteristics of a mature market, which institutional investors understand better,” he says.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Such borrowing is predicated in part on the assumption that by decontextualizing a style you also strip it of any possible negative implications: military, dynastic, what have you. It becomes an aesthetic form that exists on its own terms, as opposed to one that symbolizes all sorts of complicated societal or political convulsions.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Beck “Say Goodbye” (Capitol)
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
普华永道的校园和学校雇佣主管安德鲁?巴杰里(Andrew Bargery)表示，Teach First的毕业生出类拔萃：“他们已经在专业环境下工作过，拥有专业成熟度，并擅长交际。”
11月24日至25日，苏富比举办慕尼黑第四代交易商康拉德·伯恩海默(Konrad Bernheimer)的藏品拍卖会，他拥有历史悠久的伦敦科尔纳吉画廊(Colnaghi)。65岁的伯恩海默决定缩小自己的业务，关闭慕尼黑的画廊，卖掉巴伐利亚的豪华宅邸马尔库斯泰恩城堡(Marquartstein Castle)，将科尔纳吉画廊与伦敦的Coll & Cortes画廊合并。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
13. iPhone 提醒
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
In the ranking of finance programmes for students already working in the industry, London Business School regains the top place it occupied between 2011 and 2015, while Judge Business School at Cambridge university drops back into second place.
A facile assay for rapid detection of COVID-19 antibodies
Susan Chan, head of iShares Asia-Pacific at BlackRock, says ETFs are more popular among institutional investors in the region.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
布莱恩·肯德罗拉是纽约Stack's Bowers Galleries 拍卖行的行长，他透露这次拍卖吸引了来自6个国家的6名竞拍者。在星期四举行的拍卖会上，中标者是一名匿名的亚洲收藏家。
It is believed that the rise of South Korea's pop music industry is behind the boom, and many patients visit clinics with photos of celebrities, asking surgeons to emulate nose angle or eyes.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The central bank last year spent more than six months signaling its intent to wean the economy off a third round of bond-buying, and the prospect upset markets at just about every turn. Now it's only in the first stage of that process.
And the best gig for 2015? That would be an actuary, the people who specialize in financial risk.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The paperpot transplanter allows a single person to transplant 264 plants covering over 85ft in just minutes. What used to take hours, now takes minutes. Allowing you to spend less time transplanting crops, and more time doing other things like farm improvements, marketing, sales, or just taking some time off.
Since you will be spending so much time in your office space, you should be comfortable enough to enjoy what you do. A comfy chair will keep you pleased throughout the day. We recommend the Allak Swivel Chair, $59.99, at Ikea.com. If you need music to keep your mind stirring, we recommend the Sound System iPod Speaker, $220, at UrbanOutfiters.com.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Fewer women than men have worked abroad for at least six months (42 per cent and 52 per cent respectively) but they share exactly the same motivations — to develop management skills, build their network and increase their earnings.
The high school version of Howard isn't nearly as intimidating as the new one. Just goes to show how much ridiculous hard work goes into becoming an NBA All-Star.
Length-scale dependence of protein hydration-shell density
Alumni from Edhec have the 11th highest average salary, at $105,000, behind the alumni from Sloan at $143,600. They also enjoyed theseventh-highest salary increase, at 79 per cent.
Take the intriguing reintroduction of “unfeigned regards” — last big in the 18th century and now found on emails from Indian help centres. But the winning sign-off, at the bottom of a message sent one Friday, was: “weekend well”. I nearly awarded it second prize for the best noun pretending to be a verb, though at the last minute this award was snatched by a consultant overheard saying: “Can we cold towel that?”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Two of Summly’s employees will move to Yahoo’s California headquarters, but – for now – Mr D’Aloisio is resisting the lure of Silicon Valley.
Build the armed forces through political work and reform, and run them by law
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The life expectancy of the average human has increased more in the past 50 years than it did in the 200,000 years of human existence. Life expectancy is now 70 years old – which is a big difference from 47 years old in 1950!
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA，简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜，也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
Stand: Facebook CEO Mark Zuckerberg took a stand for immigration reform
About this collection
Folk Song “Jasmine” (Song Zuying and Celine Dion, Canada)
Emma Thompson, a two-time winner for Howards End and Sense and Sensibility, famously keeps hers in the loo: “They look far too outré anywhere else. They’re great big, gold, shiny things.” She’s not alone – Susan Sarandon, Lionel Richie and Sean Connery all claim to keep their golden fellas alongside their bidets and baths.